Modulation of Cell Surface Expression of Nonactivated Cholecystokinin Receptors Using Bivalent Ligand-Induced Internalization

द्वारा Harikumar, Kaleeckal G., Akgün, Eyup, Portoghese, Philip S., Miller, Laurence J.
प्रकाशित 2010

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

द्वारा Smeester, Branden A., Lunzer, Mary M., Akgün, Eyup, Beitz, Alvin J., Portoghese, Philip S.
में प्रकाशित Eur J Pharmacol (2014)

A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

द्वारा Dutta, Raini, Lunzer, Mary M., Auger, Jennifer L., Akgün, Eyup, Portoghese, Philip S., Binstadt, Bryce A.
में प्रकाशित Arthritis Res Ther (2018)

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception

द्वारा Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Smeester, Branden A., Beitz, Al J., Portoghese, Philip S.
प्रकाशित 2013

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

द्वारा Aceto, Mario D., Harris, Louis S., Negus, S. Stevens, Banks, Matthew L., Hughes, Larry D., Akgün, Eyup, Portoghese, Philip S.
में प्रकाशित Int J Med Chem (2012)

Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB(1)) receptors are potent analgesics devoid of tolerance

द्वारा Naour, Morgan Le, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M., Powers, Mike D., Kalyuzhny, Alexander E., Portoghese, Philip S.
प्रकाशित 2013

INHIBITION OF INFLAMMATORY AND NEUROPATHIC PAIN BY TARGETING A MU OPIOID RECEPTOR/CHEMOKINE RECEPTOR5 HETEROMER (MOR-CCR(5))

द्वारा Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Powers, Michael D., Sham, Yuk Y., Watanabe, Yoshikazu, Portoghese, Philip S.
में प्रकाशित J Med Chem (2015)

The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids

द्वारा Speltz, Rebecca, Lunzer, Mary M., Shueb, Sarah S., Akgün, Eyup, Reed, Rachelle, Kalyuzhny, Alex, Portoghese, Philip S., Simone, Donald A.
में प्रकाशित Pain (2020)

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and 2 cholecystokinin receptors

द्वारा Akgün, Eyup, Körner, Meike, Gao, Fan, Harkumar, Kaleeckal G., Waser, Beatrice, Reubi, Jean Claude, Portoghese, Philip S., Miller, Laurence J.
प्रकाशित 2009

Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK(2)) receptors by novel bivalent ligands

द्वारा Zheng, Yaguo, Akgün, Eyup, Harikumar, Kaleeckal G., Hopson, Jessika, Powers, Michael D., Lunzer, Mary M., Miller, Laurence J., Portoghese, Philip S.
प्रकाशित 2009

The Bivalent Ligand MCC22 Potently Attenuates Hyperalgesia in a Mouse Model of Cisplatin-Evoked Neuropathic Pain without Tolerance or Reward

द्वारा Cataldo, Giuseppe, Erb, Samuel J., Lunzer, Mary M., Luong, Nhungoc, Akgün, Eyup, Portoghese, Philip S., Olson, Julie K., Simone, Donald A.
में प्रकाशित Neuropharmacology (2019)

Targeting MOR-mGluR(5) heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

द्वारा Shueb, Sarah S., Erb, Samuel J., Lunzer, Mary M., Speltz, Rebecca, Harding-Rose, Catherine, Akgün, Eyup, Simone, Donald A., Portoghese, Philip S.
में प्रकाशित Neuropharmacology (2019)

The bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease

द्वारा Cataldo, Giuseppe, Lunzer, Mary M., Olson, Julie K., Akgün, Eyup, Belcher, John D., Vercellotti, Gregory M., Portoghese, Philip S., Simone, Donald A.
में प्रकाशित Pain (2018)

The combination of a delta-opioid receptor agonist and loperamide produces peripherally-mediated analgesic synergy in mice

द्वारा Bruce, Daniel.J., Peterson, Cristina.D., Kitto, Kelley. F., Akgün, Eyup., Lazzaroni, Sophia., Portoghese, Phillip.S., Fairbanks, Carolyn. A., Wilcox, George. L.
में प्रकाशित Anesthesiology (2019)

A bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice

द्वारा Peterson, Cristina D., Kitto, Kelley F., Akgün, Eyup, Lunzer, Mary M., Riedl, Maureen S., Vulchanova, Lucy, Wilcox, George L., Portoghese, Philip S., Fairbanks, Carolyn A.
में प्रकाशित Pain (2017)

Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor

द्वारा Cawston, Erin E., Lam, Polo C. H., Harikumar, Kaleeckal G., Dong, Maoqing, Ball, Alicja M., Augustine, Mary Lou, Akgün, Eyup, Portoghese, Philip S., Orry, Andrew, Abagyan, Ruben, Sexton, Patrick M., Miller, Laurence J.
प्रकाशित 2012