Resultados da pesquisa - ((eur j) OR (((((((eun j) OR (jun j))) OR (eun a))) OR (sun j)))) med chem

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chem » chen (Expandir a Pesquisa)

81

Development of phenylboronic acid-functionalized nanoparticles for emodin delivery

Development of phenylboronic acid-functionalized nanoparticles for emodin delivery

Por Wang, Bo, Chen, Limin, Sun, Yingjuan, Zhu, Youliang, Sun, Zhaoyan, An, Tiezhu, Li, Yuhua, Lin, Yuan, Fan, Daping, Wang, Qian
Publicado no J Mater Chem B Mater Biol Med (2015)

“... increased as increasing the initial PBAH concentration and the proportion of methanol. Likewise, there was a...”
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82

Tricyclic thiazoles are a new class of angiogenesis inhibitors

Tricyclic thiazoles are a new class of angiogenesis inhibitors

Por Bhat, Shridhar, Shim, Joong Sup, Liu, Jun O.
Publicado em 2013

“...Tricyclic thiazoleamine derivatives that were identified as hits in a screen against human umbilica...”
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83

Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Novel Analogs of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2- naphthyl)ethynyl]benzoic Acid (Bexarotene)

Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Novel Analogs of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2- naphthy...

Por Wagner, Carl E., Jurutka, Peter W., Marshall, Pamela A., Groy, Thomas L., van der Vaart, Arjan, Ziller, Joseph W., Furmick, Julie K., Graeber, Mark E., Matro, Erik, Miguel, Belinda V., Tran, Ivy T., Kwon, Jeng Eun S., Tedeschi, Jamie N., Moosavi, Shahram, Danishyar, Amina, Philp, Joshua S., Khamees, Reina O., Jackson, Jevon N., Grupe, Darci K., Badshah, Syed L., Hart, Justin W.
Publicado em 2009

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84

Novel Inhibitors of Bacterial Virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the Inhibition of Group A Streptococcal Streptokinase Expression

Novel Inhibitors of Bacterial Virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the Inhibition of Group A Streptococcal Streptokinase Expression

Por Yestrepsky, Bryan D., Xu, Yuanxi, Breen, Meghan E., Li, Xiaoqin, Rajeswaran, Walajapet G., Ryu, Jenny G., Sorenson, Roderick J., Tsume, Yasuhiro, Wilson, Michael W., Zhang, Wenpeng, Sun, Duxin, Sun, Hongmin, Larsen, Scott D.
Publicado em 2013

“... of the expression of streptokinase, a critical virulence factor in Group A Streptococcus that endows blood-borne...”
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85

The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

Por Sivaramakrishnan, Santhosh, Breydo, Leonid, Sun, Daekyu, Gates, Kent S.
Publicado em 2012

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86

Synthesis and characterization of a small analogue of the anticancer natural product leinamycin

Synthesis and characterization of a small analogue of the anticancer natural product leinamycin

Por Keerthi, Kripa, Rajapakse, Anuruddha, Sun, Daekyu, Gates, Kent S.
Publicado em 2012

“...Leinamycin (1) is a Streptomyces-derived natural product that displays nanomolar IC(50) values...”
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87

BBP-Functionalized Biomimetic Nanofibrous Scaffold Can Capture BMP2 and Promote Osteogenic Differentiation

BBP-Functionalized Biomimetic Nanofibrous Scaffold Can Capture BMP2 and Promote Osteogenic Differentiation

Por Yao, Qingqing, Sandhurst, Eric S., Liu, Yangxi, Sun, Hongli
Publicado no J Mater Chem B Mater Biol Med (2017)

“... that can improve the efficacy of BMPs, and thereby, use a lower dose of exogenous BMPs are highly desired...”
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88

Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents

Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents

Por Ma, Mingyi, Sun, Longru, Lou, Hongxiang, Ji, Mei
Publicado em 2013

“...BACKGROUND: Combretastatin A-4 (CA-4), which is an excellent antineoplastic agent, was isolated...”
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89

Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells

Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells

Por Rosenthal, Andrew S., Chen, Xiaochun, Liu, Jun O., West, Diana C., Hergenrother, Paul J., Shapiro, Theresa A., Posner, Gary H.
Publicado em 2009

“...A new series of 6 dimeric trioxane sulfones has been prepared from the natural trioxane artemisinin...”
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90

Radiosynthesis and Evaluation
of [(11)C-Carbonyl]-Labeled Carbamates
as Fatty Acid Amide
Hydrolase Radiotracers for Positron Emission Tomography

Radiosynthesis and Evaluation of [(11)C-Carbonyl]-Labeled Carbamates as Fatty Acid Amide Hydrolase Radiotracers for Positron Emission Tomography

Por Wilson, Alan A., Hicks, Justin W., Sadovski, Oleg, Parkes, Jun, Tong, Junchao, Houle, Sylvain, Fowler, Christopher J., Vasdev, Neil
Publicado em 2012

“...[Image: see text] Fatty acid amide hydrolase (FAAH) plays a key role in regulating the tone...”
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91

Design, Synthesis and Evaluation of Potent, Non-Peptidic Mimetics of Second Mitochondria-derived Activator of Caspases

Design, Synthesis and Evaluation of Potent, Non-Peptidic Mimetics of Second Mitochondria-derived Activator of Caspases

Por Sun, Wei, Nikolovska-Coleska, Zaneta, Qin, Dongguang, Sun, Haiying, Yang, Chao-Yie, Bai, Longchuang, Qiu, Su, Ma, Dawei, Wang, Shaomeng
Publicado em 2009

“...A series of new Smac mimetics have been designed, synthesized and evaluated. The most potent...”
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92

Hollow mesoporous silica nanoparticles for intracellular delivery of fluorescent dye

Hollow mesoporous silica nanoparticles for intracellular delivery of fluorescent dye

Por Guo, Huichen, Qian, Haisheng, Sun, Shiqi, Sun, Dehui, Yin, Hong, Cai, Xuepeng, Liu, Zaixin, Wu, Jinyan, Jiang, Tao, Liu , Xiangtao
Publicado em 2011

“... and Brunauer-Emmett-Teller (BET), to have a mesoporous layer on its surface, with an average pore diameter...”
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93

Partial Retro–Inverso, Retro, and Inverso Modifications of Hydrazide Linked Bifunctional Peptides for Opioid and Cholecystokinin (CCK) Receptors

Partial Retro–Inverso, Retro, and Inverso Modifications of Hydrazide Linked Bifunctional Peptides for Opioid and Cholecystokinin (CCK) Receptors

Por Lee, Yeon Sun, Agnes, Richard S., Davis, Peg, Ma, Shou-wu, Badghisi, Hamid, Lai, Josephine, Porreca, Frank, Hruby, Victor J.
Publicado em 2007

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94

Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs

Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs

Por Sun, Cuixiang, Hunt, Diana K., Clark, Roger B., Lofland, Denene, O’Brien, William J., Plamondon, Louis, Xiao, Xiao-Yi
Publicado em 2011

“...[Image: see text] Employing a highly efficient total synthesis approach, we synthesized...”
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95

Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

Por Lee, Yeon Sun, Agnes, Richard S., Badghisi, Hamid, Davis, Peg, Ma, Shou-wu, Lai, Josephine, Porreca, Frank, Hruby, Victor J.
Publicado em 2006

“...A series of hydrazide-linked bifunctional peptides designed to act as agonists for δ /μ opioid...”
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96

Structure–Activity Relationships of Bifunctional Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors

Structure–Activity Relationships of Bifunctional Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors

Por Agnes, Richard S., Lee, Yeon Sun, Davis, Peg, Ma, Shou-wu, Badghisi, Hamid, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Publicado em 2006

“...Cholecystokinin (CCK) has been identified as a pronociceptive endogenous peptide which also...”
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97

Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription

Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription

Por Zeller, Jörg, Turbiak, Anjanette J., Powelson, Ian A., Lee, Surin, Sun, Duxin, Hollis Showalter, H. D., Fearon, Eric R.
Publicado em 2013

“... transcriptional activity. We used xanthothricin, a known β-catenin/TCF antagonist of microbial origin, as a lead...”
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98

Cytosine-Based TET Enzyme Inhibitors

Cytosine-Based TET Enzyme Inhibitors

Por Chua, Gabriella N. L., Wassarman, Kelly L., Sun, Haoyu, Alp, Joseph A., Jarczyk, Emma I., Kuzio, Nathanael J., Bennett, Michael J., Malachowsky, Beth G., Kruse, Martin, Kennedy, Andrew J.
Publicado no ACS Med Chem Lett (2019)

“..., synthesis, and evaluation of novel cytosine-based TET enzyme inhibitors, a class of small molecule probes...”
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99

Structural and Stereochemical Requirements of the Spiroketal Group of Hippuristanol for Antiproliferative Activity

Structural and Stereochemical Requirements of the Spiroketal Group of Hippuristanol for Antiproliferative Activity

Por Li, Wei, Dang, Yongjun, Liu, Jun O., Yu, Biao
Publicado em 2010

“...Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation...”
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100

Extracellular and Intracellular Esterase Processing of SCFA-Hexosamine Analogs: Implications for Metabolic Glycongineering and Drug Delivery

Extracellular and Intracellular Esterase Processing of SCFA-Hexosamine Analogs: Implications for Metabolic Glycongineering and Drug Delivery

Por Mathew, Mohit P., Tan, Elaine, Shah, Shivam, Bhattacharya, Rahul, Meledeo, M. Adam, Huang, Jun, Espinoza, Freddy A., Yarema, Kevin J.
Publicado em 2012

“...This report provides a synopsis of the esterase processing of short chain fatty acid (SCFA...”
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