Radiosynthesis and Evaluation of [(11)C-Carbonyl]-Labeled Carbamates as Fatty Acid Amide Hydrolase Radiotracers for Positron Emission Tomography

[Image: see text] Fatty acid amide hydrolase (FAAH) plays a key role in regulating the tone of the endocannabinoid system. Radiotracers are required to image and quantify FAAH activity in vivo. We have synthesized a series of potent FAAH inhibitors encompassing two classes of N-alkyl-O-arylcarbamate...

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Detalhes bibliográficos
Main Authors: Wilson, Alan A., Hicks, Justin W., Sadovski, Oleg, Parkes, Jun, Tong, Junchao, Houle, Sylvain, Fowler, Christopher J., Vasdev, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544278/
https://ncbi.nlm.nih.gov/pubmed/23214511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301492y
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