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Structure–Activity Relationships of Bifunctional Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors
Cholecystokinin (CCK) has been identified as a pronociceptive endogenous peptide which also possesses antiopioid actions. CCK may be upregulated in conditions of chronic pain or during sustained morphine administration resulting in attenuation of opioid-mediated pain relief. These complex interactio...
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Autores principales: | , , , , , , , |
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Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
2006
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1484468/ https://ncbi.nlm.nih.gov/pubmed/16686530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050921q |
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