Structure–Activity Relationships of Bifunctional Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors

Cholecystokinin (CCK) has been identified as a pronociceptive endogenous peptide which also possesses antiopioid actions. CCK may be upregulated in conditions of chronic pain or during sustained morphine administration resulting in attenuation of opioid-mediated pain relief. These complex interactio...

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Detalhes bibliográficos
Main Authors: Agnes, Richard S., Lee, Yeon Sun, Davis, Peg, Ma, Shou-wu, Badghisi, Hamid, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484468/
https://ncbi.nlm.nih.gov/pubmed/16686530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050921q
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