Opioid and Melanocortin Receptors: Do They Have Opioid Overlapping Pharmacophores?

We have identified compound 1 as a novel ligand for opioid and melanocortin (MC) receptors, which is derived from the overlapping of a well known structure for the δ opioid receptor, 2,6-dimethyltyrosine (Dmt)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic), and a small molecule for the MC re...

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Autors principals: Lee, Yeon Sun, Agnes, Richard S., Cain, James P., Kulkarni, Vinod, Cai, Minying, Salibay, Christine, Ciano, Kathy, Petrov, Ravil, Mayorov, Alexander, Vagner, Josef, Trivedi, Dev, Davis, Peg, Ma, Shou-wu, Lai, Josephine, Porreca, Frank, Vardanyan, Ruben, Hruby, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693099/
https://ncbi.nlm.nih.gov/pubmed/17657709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.20814
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