Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain

It has been known that co-administration of morphine with either cholecystokinin(CCK) receptor or melanocortin (MC) receptor antagonists enhance morphine's analgesic efficacy by reducing serious side effects such as tolerance and addiction.1–4 Considering these synergistic effects, we have desi...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Yeon Sun, Fernandes, Steve, Kulkarani, Vinod, Mayorov, Alexander, Davis, Peg, Ma, Shou-wu, Brown, Kathy, Gillies, Robert J., Lai, Josephine, Porreca, Frank, Hruby, Victor J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917332/
https://ncbi.nlm.nih.gov/pubmed/20547453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.05.078
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