Partial Retro–Inverso, Retro, and Inverso Modifications of Hydrazide Linked Bifunctional Peptides for Opioid and Cholecystokinin (CCK) Receptors

Partially modified retro–inverso, retro, and inverso isomers of hydrazide linked bifunctional peptides were designed, synthesized, and evaluated for bioactivities at δ/μ opioid receptors and CCK-1/CCK-2 receptors. All modifications of the CCK pharmacophore moiety affected bioactivities for the CCK-1...

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Main Authors: Lee, Yeon Sun, Agnes, Richard S., Davis, Peg, Ma, Shou-wu, Badghisi, Hamid, Lai, Josephine, Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365893/
https://ncbi.nlm.nih.gov/pubmed/17201419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061268p
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