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Development of novel enkephalin analogues which have enhanced opioid activities at both μ and δ opioid receptors
Enkephalin analogues with an 4-anilidopiperidine scaffold have been designed and synthesized to achieve therapeutic benefit for the treatment of pain due to mixed μ and δ opioid agonist activities. Ligand 16, in which a Dmt-substituted enkephalin-like structure was linked to the N-phenyl-N-piperidin...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678914/ https://ncbi.nlm.nih.gov/pubmed/17927164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061465o |
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