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Development of novel enkephalin analogues which have enhanced opioid activities at both μ and δ opioid receptors

Enkephalin analogues with an 4-anilidopiperidine scaffold have been designed and synthesized to achieve therapeutic benefit for the treatment of pain due to mixed μ and δ opioid agonist activities. Ligand 16, in which a Dmt-substituted enkephalin-like structure was linked to the N-phenyl-N-piperidin...

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Bibliografische gegevens
Hoofdauteurs: Lee, Yeon Sun, Petrov, Ravil, Park, Chad K., Ma, Shou-wu, Davis, Peg, Lai, Josephine, Porreca, Frank, Vardanyan, Ruben, Hruby, Victor J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678914/
https://ncbi.nlm.nih.gov/pubmed/17927164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061465o
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