Resultados da pesquisa - ((eun a) OR (((((eun au) OR (eun auu))) OR (((sun j) OR (sun y)))))) med chem

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Microbeads-Guided Reconstruction of 3D Osteocyte Network during Microfluidic Perfusion Culture

Por Gu, Yexin, Zhang, Wenting, Sun, Qiaoling, Hao, Yi, Zilberberg, Jenny, Lee, Woo Y.
Publicado no J Mater Chem B Mater Biol Med (2015)

“... best knowledge, the use of a biomimetic approach to reconstruct the 3D osteocyte network...”
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(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5

Por Blasdel, Landy K., Lee, DongEun, Sun, Binyuan, Myers, Andrew G.
Publicado em 2013

“...Analogs of salinsporamide A with variations of the C2 and C5 substituents are prepared in 8–10...”
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A Glimpse of Matrix Metalloproteinases in Diabetic Nephropathy

Por Xu, X., Xiao, L., Xiao, P., Yang, S., Chen, G., Liu, F., Kanwar, Y.Y., Sun, L.
Publicado no Curr Med Chem (2014)

“... (ECM). It is known that MMPs play a role in a number of renal diseases, such as, various forms...”
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Synthesis and Structure-Activity Relationships of Linear and Conformationally Constrained Peptide Analogs of CIYKYY as Src Tyrosine Kinase Inhibitors

Por Kumar, Anil, Ye, Guofeng, Wang, Yuehao, Lin, Xiaofeng, Sun, Gongqin, Parang, Keykavous
Publicado em 2006

“...A series of peptide analogs of Ac-CIYKYY (1) were synthesized by functional group modifications...”
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Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1

Por Prior, Allan M., Yu, Xufen, Park, Eun-Jung, Kondratyuk, Tamara P., Lin, Yan, Pezzuto, John M., Sun, Dianqing
Publicado no Bioorg Med Chem Lett (2017)

“...In our ongoing effort of discovering anticancer and chemopreventive agents, a series of 2...”
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Cyclic Peptides Containing Tryptophan and Arginine as Src Kinase Inhibitors

Por Shirazi, Amir Nasrolahi, Tiwari, Rakesh Kumar, Brown, Alex, Mandal, Dindyal, Sun, Gongqin, Parang, Keykavous
Publicado em 2013

“... and polyE(4)Y as the substrate. C[RW](5) was a non-competitive Src kinase inhibitor, showing approximately 4...”
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Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents

Por Shen, Li, Park, Eun-Jung, Kondratyuk, Tamara P., Guendisch, Daniela, Marler, Laura, Pezzuto, John M., Wright, Anthony D., Sun, Dianqing
Publicado em 2011

“...Callophycin A was originally isolated from the red algae Callophycus oppositifolius and shown...”
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Structure–Activity Studies of Divin: An Inhibitor of Bacterial Cell Division

Por Zhou, Maoquan, Eun, Ye-Jin, Guzei, Ilia A., Weibel, Douglas B.
Publicado em 2013

“... of divin, a small molecule that blocks bacterial division by perturbing the assembly of proteins...”
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Cyclic opioid peptides

Por Remesic, Michael, Lee, Yeon Sun, Hruby, Victor J.
Publicado no Curr Med Chem (2016)

“... of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have...”
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Simultaneous determination of methylcarbamate and ethylcarbamate in fermented foods and beverages by derivatization and GC-MS analysis

Por Shin, Ho-Sang, Yang, Eun-Young
Publicado em 2012

“... in fermented food and beverages. In order to estimate the risk for their exposure, a sensitive simultaneous...”
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Dynorphin A analogs for the treatment of chronic neuropathic pain

Por Hall, Sara M, Lee, Yeon Sun, Hruby, Victor J
Publicado no Future Med Chem (2016)

“... states. The endogenous peptide, dynorphin A has long been established as a target for the treatment...”
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Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor

Por Fernandes, Steve M., Lee, Yeon Sun, Gillies, Robert J., Hruby, Victor J.
Publicado no Bioorg Med Chem (2014)

“..., synthesized, and tested a series of bivalent ligands targeting the over-expressed human melanocortin 4...”
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Structure Activity Relationships of 1,4-Dihydropyridines That Act as Enhancers of the Vanilloid Receptor 1 (TRPV1)

Por Roh, Eun Joo, Keller, Jason M., Olah, Zoltan, Iadarola, Michael J., Jacobson, Kenneth A.
Publicado em 2008

“...Vanilloid agonists such as capsaicin activate ion flux through the TRPV1 channel, a heat...”
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Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host

Por Sun, Jun
Publicado em 2009

“... Salmonella AvrA, Enteropathogenic Escherichia coli Cif, and Yersinia YopJ, Staphylococcus aureus...”
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2-(3-Fluoro-4-methylsulfonylaminophenyl) Propanamides as Potent Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists: Structure Activity Relationships of 2-Amino Derivative...

Por Kim, Myeong Seop, Ryu, HyungChul, Kang, Dong Wook, Cho, Seong-Hee, Seo, Sejin, Park, Young Soo, Kim, Mi-Yeon, Kwak, Eun Joo, Kim, Yong Soo, Bhondwe, Rahul S., Kim, Ho Shin, Park, Seul-gi, Son, Karam, Choi, Sun, DeAndrea-Lazarus, Ian, Pearce, Larry V., Blumberg, Peter M., Frank, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Kögel, Babette Y., Schiene, Klaus, Christoph, Thomas, Lee, Jeewoo
Publicado em 2012

“...A series of N-(2-amino-6-trifluoromethyl-pyridin-3-ylmethyl) 2-(3-fluoro-4...”
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Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 6. Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine

Por Wentland, Mark P., Sun, Xufeng, Cohen, Dana J., Bidlack, Jean M.
Publicado em 2008

“...A series of 7,8- and 8,9-fused pyrimidinone, aminopyridine and pyridone derivatives of 8...”
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Synthesis and Comparative Biological Evalution of Bifunctional Ligands for Radiotherapy Applications of (90)Y and (177)Lu

Por Chong, Hyun-Soon, Sun, Xiang, Chen, Yunwei, Sin, Inseok, Kang, Chi Soo, Lewis, Michael R., Liu, Dijie, Ruthengael, Varyanna C., Zhong, Yongliang, Wu, Ningjie, Song, Hyun A
Publicado no Bioorg Med Chem (2014)

“...Zevalin® is an antibody-drug conjugate radiolabeled with a cytotoxic radioisotope ((90)Y...”
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Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel

Por Sun, Liang, Veith, Jean M., Pera, Paula, Bernacki, Ralph J., Ojima, Iwao
Publicado em 2010

“...Novel paclitaxel-mimicking alkaloids were designed and synthesized based on a bioactive...”
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Labeled Ligand Displacement: Extending NMR-Based Screening of Protein Targets

Por Swann, Steven L., Song, Danying, Sun, Chaohong, Hajduk, Philip J., Petros, Andrew M.
Publicado em 2010

“...[Image: see text] NMR spectroscopy has enjoyed widespread success as a method for screening protein...”
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Semantic inference using chemogenomics data for drug discovery

Por Zhu, Qian, Sun, Yuyin, Challa, Sashikiran, Ding, Ying, Lajiness, Michael S, Wild, David J
Publicado em 2011

“... such as LODD, Bio2RDF, and Chem2Bio2RDF. Integration of these sets creates large networks of information. We...”
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