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Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor

Membrane proteins, especially G-protein coupled receptors (GPCRs), are interesting and important theragnostic targets since many of them serve in intracellular signaling critical for all aspects of health and disease. The potential utility of designed bivalent ligands as targeting agents for cancer...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Fernandes, Steve M., Lee, Yeon Sun, Gillies, Robert J., Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254589/
https://ncbi.nlm.nih.gov/pubmed/25438759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.055
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