Synthesis and Characterization of a Eu-DTPA-PEGO-MSH(4) Derivative for Evaluation of Binding of Multivalent Molecules to Melanocortin Receptors1

A labeled variant of MSH(4), a tetrapeptide that binds to the human melanocortin 4 receptor (hMC4R) with low µM affinity, was prepared by solid phase synthesis methods, purified, and characterized. The labeled ligand, Eu-DTPA-PEGO-His-dPhe-Arg-Trp-NH(2), exhibited a K(d) for hMC4R of 9.1±1.4 µM, app...

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Detalhes bibliográficos
Main Authors: Xu, Liping, Vagner, Josef, Alleti, Ramesh, Rao, Venkataramanarao, Jagadish, Bhumasamudram, Morse, David L., Hruby, Victor J., Gillies, Robert J., Mash, Eugene A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857964/
https://ncbi.nlm.nih.gov/pubmed/20304640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.03.007
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