Synthesis and Comparative Biological Evalution of Bifunctional Ligands for Radiotherapy Applications of (90)Y and (177)Lu

Zevalin® is an antibody-drug conjugate radiolabeled with a cytotoxic radioisotope ((90)Y) that was approved for radioimmunotherapy (RIT) of B-cell non-Hodgkin’s lymphoma. A bifunctional ligand that displays favorable complexation kinetics and in vivo stability is required for effective RIT. New bifu...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Chong, Hyun-Soon, Sun, Xiang, Chen, Yunwei, Sin, Inseok, Kang, Chi Soo, Lewis, Michael R., Liu, Dijie, Ruthengael, Varyanna C., Zhong, Yongliang, Wu, Ningjie, Song, Hyun A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376478/
https://ncbi.nlm.nih.gov/pubmed/25648683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.035
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