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Synthesis and Preclinical Evaluation of Bifunctional Ligands for Improved Chelation Chemistry of (90)Y and (177)Lu for Targeted Radioimmunotherapy
We report a practical and high yield synthesis of a bimodal bifunctional ligand 3p-C-NETA-NCS containing the isothiocyanate group for conjugation to a tumor targeting antibody. 3p-C-NETA-NCS was conjugated to a tumor-targeting antibody, trastuzumab, and the corresponding 3p-C-NETA-trastuzumab conjug...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3447103/ https://ncbi.nlm.nih.gov/pubmed/22881720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200696b |
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