Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1

In our ongoing effort of discovering anticancer and chemopreventive agents, a series of 2-arylindole derivatives were synthesized and evaluated toward aromatase and quinone reductase 1 (QR1). Biological evaluation revealed that several compounds (e.g., 2d, IC(50) = 1.61 μM; 21, IC(50) = 3.05 μM; and...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Prior, Allan M., Yu, Xufen, Park, Eun-Jung, Kondratyuk, Tamara P., Lin, Yan, Pezzuto, John M., Sun, Dianqing
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705205/
https://ncbi.nlm.nih.gov/pubmed/29153737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.11.010
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