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Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1
In our ongoing effort of discovering anticancer and chemopreventive agents, a series of 2-arylindole derivatives were synthesized and evaluated toward aromatase and quinone reductase 1 (QR1). Biological evaluation revealed that several compounds (e.g., 2d, IC(50) = 1.61 μM; 21, IC(50) = 3.05 μM; and...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5705205/ https://ncbi.nlm.nih.gov/pubmed/29153737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.11.010 |
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