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Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities

An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors. In add...

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Detalhes bibliográficos
Main Authors: Maiti, Arup, Narasimha Reddy, P. V., Sturdy, Megan, Marler, Laura, Pegan, Scott D., Mesecar, Andrew D., Pezzuto, John M., Cushman, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673050/
https://ncbi.nlm.nih.gov/pubmed/19265439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801335z
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