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X-ray structural studies of quinone reductase 2 nanomolar range inhibitors

Quinone reductase 2 (QR2) is one of two members comprising the mammalian quinone reductase family of enzymes responsible for performing FAD mediated reductions of quinone substrates. In contrast to quinone reductase 1 (QR1) which uses NAD(P)H as its co-substrate, QR2 utilizes a rare group of hydride...

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Detalhes bibliográficos
Main Authors: Pegan, Scott D, Sturdy, Megan, Ferry, Gilles, Delagrange, Philippe, Boutin, Jean A, Mesecar, Andrew D
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149192/
https://ncbi.nlm.nih.gov/pubmed/21538647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.647
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