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Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2

Melatonin exerts its biological effects through at least two transmembrane G-protein-coupled receptors, MT1 and MT2, and a lower-affinity cytosolic binding site, designated MT3. MT3 has recently been identified as QR2 (quinone reductase 2) (EC 1.10.99.2) which is of significance since it links the a...

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Bibliografiske detaljer
Main Authors: CALAMINI, Barbara, SANTARSIERO, Bernard D., BOUTIN, Jean A., MESECAR, Andrew D.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265362/
https://ncbi.nlm.nih.gov/pubmed/18254726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20071373
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