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Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms

Por Korayem, Adam H., Mujica, Patricio E., Aramoto, Haruo, Durán, Ricardo G., Nepali, Prerna R., Kim, David D., Harris, Andrew L., Sánchez, Fabiola A., Durán, Walter N.
Publicado no Am J Physiol Heart Circ Physiol (2017)

“... deactivates hyperpermeability, and 3) cAMP activates the Epac1-Rap1 pathway to restore normal microvascular...”
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Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase.

Por Bergold, P J, Sweatt, J D, Winicov, I, Weiss, K R, Kandel, E R, Schwartz, J H
Publicado em 1990

“...Depending on the number or the length of exposure, application of serotonin can produce either...”
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Laminin enhances β(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes

Por Pabbidi, M R, Ji, X, Samarel, A M, Lipsius, S L
Publicado em 2009

“...-β(2)-AR stimulation of I(Ca,L), which was unchanged by AACOCF(3). Inhibition of ERK1/2 by 1 μm U0126...”
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Caffeine accelerates recovery from general anesthesia via multiple pathways

Por Fong, Robert, Khokhar, Suhail, Chowdhury, Atif N., Xie, Kelvin G, Wong, Josiah Hiu-Yuen, Fox, Aaron P., Xie, Zheng
Publicado no J Neurophysiol (2017)

“... have shown that three drugs that elevate intracellular cAMP (forskolin, theophylline, and caffeine...”
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Coupling of β2-Adrenoceptors to XLα(s) and Gα(s): A New Insight into Ligand-Induced G Protein Activation

Por Kaya, A. I., Uǧur, Ö., Öner, S. S., Bastepe, M., Onaran, H. O.
Publicado em 2009

“...Gα(s) and extra-large Gα(s) (XLα(s)) can both transduce receptor activation into intracellular cAMP...”
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A Stochastic Model for Chemotaxis Based on the Ordered Extension of Pseudopods

Por Van Haastert, Peter J.M.
Publicado em 2010

“...Many amoeboid cells move by extending pseudopods. Here I present a new stochastic model...”
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Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Por Conley, Jason M., Brust, Tarsis F., Xu, Ruqiang, Burris, Kevin D., Watts, Val J.
Publicado em 2014

“.... This new format is amenable to small molecule screening, and we demonstrate that this assay design can also...”
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The P2Y(12) Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a G(i)-independent Increase in cAMP Levels

Por Srinivasan, Subhashini, Mir, Fozia, Huang, Jin-Sheng, Khasawneh, Fadi T., Lam, Stephen C.-T., Le Breton, Guy C.
Publicado em 2009

“... demonstrated that this elevation of cAMP did not require G(i) signaling or functional P2Y(12) receptors...”
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Changing trends in elephant camp management in northern Thailand and implications for welfare

Por Bansiddhi, Pakkanut, Brown, Janine L., Thitaram, Chatchote, Punyapornwithaya, Veerasak, Somgird, Chaleamchat, Edwards, Katie L., Nganvongpanit, Korakot
Publicado no PeerJ (2018)

“... many countries. A wide range of management strategies are used by these camps, which can have varied...”
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NEW INSIGHTS INTO THE PROTEASOME FUNCTION AND DEGRADATION OF MISFOLDED PROTEINS

Por Goldberg, A, Lokireddy, S, Kim, H, Kuo, C, VerPlank, J
Publicado no Innov Aging (2018)

“.... The mammalian proteasome activity can be modulated by agents that raise cAMP and activate Protein Kinase A. PKA...”
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Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A(2) and is differently regulated by cyclic AMP and...

Por Strokin, Mikhail, Sergeeva, Marina, Reiser, Georg
Publicado em 2003

“... stimulated by ATP. 7. Different sensitivities of iPLA(2) and cPLA(2) to Ca(2+) and cAMP reveal new pathways...”
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Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene.

Por Tsukada, J, Saito, K, Waterman, W R, Webb, A C, Auron, P E
Publicado em 1994

“... LPS-responsive sequence which can be modulated by cAMP as a result of the involvement of NF-IL6-CRE...”
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Cftr: Covalent Modification of Cysteine-Substituted Channels Expressed in Xenopus Oocytes Shows That Activation Is Due to the Opening of Channels Resident in the Plasma Membrane

Por Liu, Xuehong, Smith, Stephen S., Sun, Fang, Dawson, David C.
Publicado em 2001

“...Some studies of CFTR imply that channel activation can be explained by an increase in open...”
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Cyclic AMP and Polyamines Overcome Inhibition by Myelin-Associated Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5

Por He, Huifang, Deng, Kangwen, Siddiq, Mustafa M., Pyie, Aung, Mellado, Wilfredo, Hannila, Sari S., Filbin, Marie T.
Publicado no J Neurosci (2016)

“...), can block the inhibitory effects of MAG and myelin. We have also shown that elevation of cAMP results...”
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Changing trends in elephant camp management in northern Thailand and implications for welfare

Por Pakkanut Bansiddhi, Janine L. Brown, Chatchote Thitaram, Veerasak Punyapornwithaya, Chaleamchat Somgird, Katie L. Edwards, Korakot Nganvongpanit
Publicado em 2018-11-01

Assuntos: “...Elephant camp...”
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A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI) to the Plasma Membrane

Por Burgers, Pepijn P., Ma, Yuliang, Margarucci, Luigi, Mackey, Mason, van der Heyden, Marcel A. G., Ellisman, Mark, Scholten, Arjen, Taylor, Susan S., Heck, Albert J. R.
Publicado em 2012

“... of AKAPs, providing a new perspective on spatio-temporal control of cAMP signaling....”
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Transducin-Like Enhancer of Split-6 (TLE6) Is a Substrate of Protein Kinase A Activity During Mouse Oocyte Maturation

Por Duncan, Francesca E., Padilla-Banks, Elizabeth, Bernhardt, Miranda L., Ord, Teri S., Jefferson, Wendy N., Moss, Stuart B., Williams, Carmen J.
Publicado no Biol Reprod (2014)

“... meiotic progression after the prophase I arrest and offer new insights into downstream targets of its...”
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Anti-diabetic biguanides inhibit hormone-induced intracellular Ca2+ concentration oscillations in rat hepatocytes.

Por Ubl, J J, Chen, S, Stucki, J W
Publicado em 1994

“... the frequency of the [Ca2+]i oscillations in a concentration-dependent manner with an IC50 of 0.1 mM and 1...”
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SUN-502 From Pseudohypoparathyroidism to Signaling Disorder

Por Imam, Ahmad, Taha, Wael
Publicado no J Endocr Soc (2019)

“... using inactivating PTH/PTHrP signaling disorder (iPPSD) instead of PHP and has published a new approach...”
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Association Mapping and Significance Estimation via the Coalescent

Por Kimmel, Gad, Karp, Richard M., Jordan, Michael I., Halperin, Eran
Publicado em 2008

“... not better than the standard approach of separate testing of SNPs. We suggest a new genealogy-based approach...”
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