The P2Y(12) Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a G(i)-independent Increase in cAMP Levels

ADP plays an integral role in the process of hemostasis by signaling through two platelet G-protein-coupled receptors, P2Y(1) and P2Y(12). The recent use of antagonists against these two receptors has contributed a substantial body of data characterizing the ADP signaling pathways in human platelets...

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Detalhes bibliográficos
Main Authors: Srinivasan, Subhashini, Mir, Fozia, Huang, Jin-Sheng, Khasawneh, Fadi T., Lam, Stephen C.-T., Le Breton, Guy C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713557/
https://ncbi.nlm.nih.gov/pubmed/19346255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809780200
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