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The P2Y(12) Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a G(i)-independent Increase in cAMP Levels
ADP plays an integral role in the process of hemostasis by signaling through two platelet G-protein-coupled receptors, P2Y(1) and P2Y(12). The recent use of antagonists against these two receptors has contributed a substantial body of data characterizing the ADP signaling pathways in human platelets...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713557/ https://ncbi.nlm.nih.gov/pubmed/19346255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809780200 |
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