Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Sensitization of adenylyl cyclase (AC) signaling has been implicated in a variety of neuropsychiatric and neurologic disorders including substance abuse and Parkinson's disease. Acute activation of Gαi/o-linked receptors inhibits AC activity, whereas persistent activation of these receptors res...

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Autores principales: Conley, Jason M., Brust, Tarsis F., Xu, Ruqiang, Burris, Kevin D., Watts, Val J.
Formato: Artigo
Lenguaje:Inglês
Publicado: MyJove Corporation 2014
Materias:
Bioengineering
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990329/
https://ncbi.nlm.nih.gov/pubmed/24514897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/51218
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