Development of a High-Throughput Screening Paradigm for the Discovery of Small-Molecule Modulators of Adenylyl Cyclase: Identification of an Adenylyl Cyclase 2 Inhibitor

Adenylyl cyclase (AC) isoforms are implicated in several physiologic processes and disease states, but advancements in the therapeutic targeting of AC isoforms have been limited by the lack of potent and isoform-selective small-molecule modulators. The discovery of AC isoform-selective small molecul...

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Detalhes bibliográficos
Principais autores: Conley, Jason M., Brand, Cameron S., Bogard, Amy S., Pratt, Evan P. S., Xu, Ruqiang, Hockerman, Gregory H., Ostrom, Rennolds S., Dessauer, Carmen W., Watts, Val J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Cellular and Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807067/
https://ncbi.nlm.nih.gov/pubmed/24008337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.207449
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