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Identification of a selective small molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties
Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that inhibitors of AC1 may be useful for treating pain and opioid dependence. However, non-selective inhibition of AC isoform...
Enregistré dans:
| Publié dans: | Sci Signal |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5734633/ https://ncbi.nlm.nih.gov/pubmed/28223412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aah5381 |
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