Identification of a selective small molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties

Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that inhibitors of AC1 may be useful for treating pain and opioid dependence. However, non-selective inhibition of AC isoform...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Brust, Tarsis F., Alongkronrusmee, Doungkamol, Soto-Velasquez, Monica, Baldwin, Tanya A., Ye, Zhishi, Dai, Mingji, Dessauer, Carmen W., van Rijn, Richard M., Watts, Val J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734633/
https://ncbi.nlm.nih.gov/pubmed/28223412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aah5381
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