Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms

Approaches to reduce excessive edema due to the microvascular hyperpermeability that occurs during ischemia-reperfusion (I/R) are needed to prevent muscle compartment syndrome. We tested the hypothesis that cAMP-activated mechanisms actively restore barrier integrity in postischemic striated muscle....

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Korayem, Adam H., Mujica, Patricio E., Aramoto, Haruo, Durán, Ricardo G., Nepali, Prerna R., Kim, David D., Harris, Andrew L., Sánchez, Fabiola A., Durán, Walter N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538859/
https://ncbi.nlm.nih.gov/pubmed/28476918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00002.2017
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