NEW INSIGHTS INTO THE PROTEASOME FUNCTION AND DEGRADATION OF MISFOLDED PROTEINS

Protein degradation by the UPS is controlled through ubiquitin conjugation and control of proteasome activity. Most 26S proteasomes are in a latent state, but bindings of ubiquitinated proteins enhance its capacity to hydrolyze substrates and stimulates binding of key cofactors. Proteasome function...

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發表在:Innov Aging
Main Authors: Goldberg, A, Lokireddy, S, Kim, H, Kuo, C, VerPlank, J
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
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Abstracts
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6228170/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy023.1443
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