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NEW INSIGHTS INTO THE PROTEASOME FUNCTION AND DEGRADATION OF MISFOLDED PROTEINS
Protein degradation by the UPS is controlled through ubiquitin conjugation and control of proteasome activity. Most 26S proteasomes are in a latent state, but bindings of ubiquitinated proteins enhance its capacity to hydrolyze substrates and stimulates binding of key cofactors. Proteasome function...
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| Publicado no: | Innov Aging |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6228170/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy023.1443 |
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