A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI) to the Plasma Membrane

Protein kinase A-anchoring proteins (AKAPs) provide spatio-temporal specificity for the omnipotent cAMP-dependent protein kinase (PKA) via high affinity interactions with PKA regulatory subunits (PKA-RI, RII). Many PKA-RII-AKAP complexes are heavily tethered to cellular substructures, whereas PKA-RI...

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Autors principals: Burgers, Pepijn P., Ma, Yuliang, Margarucci, Luigi, Mackey, Mason, van der Heyden, Marcel A. G., Ellisman, Mark, Scholten, Arjen, Taylor, Susan S., Heck, Albert J. R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527963/
https://ncbi.nlm.nih.gov/pubmed/23115245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395970
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