Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection

PKA is retained within distinct subcellular environments by the association of its regulatory type II (RII) subunits with A-kinase anchoring proteins (AKAPs). Conventional reagents that universally disrupt PKA anchoring are patterned after a conserved AKAP motif. We introduce a phage selection proce...

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Autors principals: Gold, Matthew G., Fowler, Douglas M., Means, Christopher K., Pawson, Catherine T., Stephany, Jason J., Langeberg, Lorene K., Fields, Stanley, Scott, John D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682517/
https://ncbi.nlm.nih.gov/pubmed/23625929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.447326
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