Resultados da pesquisa - (( drug doses devel ther ) OR ((( drug de leves rate ) OR ( drug dosage live ther ))))

181

Ketamine and depression: a narrative review

Por Corriger, Alexandrine, Pickering, Gisèle
Publicado no Drug Des Devel Ther (2019)

“.... Safety and tolerability profiles with ketamine at low single dose are generally good in depressed...”
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182

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Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway

Por Chen, Yanhua, Zhang, Xu, Zhang, Bingdong, He, Guodong, Zhou, Lifang, Xie, Yubo
Publicado no Drug Des Devel Ther (2017)

“... of dexmedetomidine on neuronal apoptosis caused by CPB. Here, rats were treated with different doses...”
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183

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Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

Por Marchal, Juan Antonio, Carrasco, Esther, Ramirez, Alberto, Jiménez, Gema, Olmedo, Carmen, Peran, Macarena, Agil, Ahmad, Conejo-García, Ana, Cruz-López, Olga, Campos, Joaquin María, García, María Ángel
Publicado em 2013

“... great potential of this synthetic drug in the treatment of cancer. We identified that the double...”
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184

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Transient hypofibrinogenemia due to allopurinol

Por Yin, ZhiQiang, Xu, JiaLi, Li, YongQiang, Xia, JiPing, Luo, Dan
Publicado em 2014

“...This study reports a case of an 80-year-old male who suffered from drug eruption due to oral...”
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185

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Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Por Zaid, Abdel Naser, Abualhasan, Murad N, Watson, David G, Mousa, Ayman, Ghazal, Nadia, Bustami, Rana
Publicado no Drug Des Devel Ther (2015)

“... healthy male volunteers with a 9-day washout period between doses and under fasting conditions. The drug...”
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186

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Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Por Mumoli, Laura, Palleria, Caterina, Gasparini, Sara, Citraro, Rita, Labate, Angelo, Ferlazzo, Edoardo, Gambardella, Antonio, De Sarro, Giovambattista, Russo, Emilio
Publicado no Drug Des Devel Ther (2015)

“... requires dose adjustment. BRV does not seem to influence other antiepileptic drug plasma levels. Six...”
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187

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Comparative pharmacokinetics and pharmacodynamics of a PEGylated recombinant human growth hormone and daily recombinant human growth hormone in growth hormone-deficient children

Por Hou, Ling, Chen, Zhi-hang, Liu, Dong, Cheng, Yuan-guo, Luo, Xiao-ping
Publicado no Drug Des Devel Ther (2015)

“... the pharmacokinetics, pharmacodynamics, safety, and tolerability of multiple sc doses of Jintrolong(®) vs daily doses...”
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188

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Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis

Por Cuffari, Carmen, Pierce, David, Korczowski, Bartosz, Fyderek, Krzysztof, Van Heusen, Heather, Hossack, Stuart, Wan, Hong, Edwards, Alena YZ, Martin, Patrick
Publicado no Drug Des Devel Ther (2016)

“.... Blood samples were collected pre-dose on days 5 and 6. On days 7 and 8, blood and urine samples were...”
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189

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A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers

Por Golor, Georg, Hu, Ke, Ruffin, Matthieu, Buchelt, Alexandra, Bouillaud, Emmanuel, Wang, Yanfeng, Maldonado, Mario
Publicado em 2012

“..., and neuroendocrine tumors (NET). This manuscript reports the first-in-man dose-escalation study of pasireotide...”
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190

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A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist

Por Hoch, Matthias, Darpo, Borje, Remenova, Tatiana, Stoltz, Randall, Zhou, Meijian, Kaufmann, Priska, Bruderer, Shirin, Dingemanse, Jasper
Publicado no Drug Des Devel Ther (2014)

“... were randomized to receive escalating doses of selexipag (n=91) or placebo/moxifloxacin (n=68...”
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191

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Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

Por Ahmad, Waqas, Jantan, Ibrahim, Kumolosasi, Endang, Bukhari, Syed Nasir Abbas
Publicado no Drug Des Devel Ther (2015)

“... Wistar Kyoto rats were treated daily at 100 mg/kg, 200 mg/kg, and 400 mg/kg doses of the extract for 21...”
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192

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Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

Por Kim, Choon Ok, Oh, Eun Sil, Choi, Chungam, Kim, Yeonjoo, Lee, Sera, Kim, Semi, Park, Min Soo
Publicado no Drug Des Devel Ther (2016)

“... the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult...”
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193

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The role of IL-1 inhibition in systemic juvenile idiopathic arthritis: current status and future perspectives

Por Toplak, Nataša, Blazina, Štefan, Avčin, Tadej
Publicado no Drug Des Devel Ther (2018)

“... of biologic therapy, treatment of SJIA was primarily based on long-term treatment with high doses...”
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194

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A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

Por Yang, Yejin, Kim, Wooseong, Kim, Dayoon, Jeong, Seongkeun, Yoo, Jin-Wook, Jung, Yunjin
Publicado no Drug Des Devel Ther (2018)

“...-dinitrobenzene sulfonic acid hydrate (DNBS)-induced colitis, MCP-azo-ASA alleviated colonic damage in a dose...”
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195

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Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation

Por Abdel-Wahab, Wessam M, Moussa, Farouzia I
Publicado no Drug Des Devel Ther (2019)

“...) at two different doses in the management of CDDP-induced toxicity in rat brain by monitoring its...”
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196

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New developments in the management of partial-onset epilepsy: role of brivaracetam

Por Coppola, Giangennaro, Iapadre, Giulia, Operto, Francesca Felicia, Verrotti, Alberto
Publicado no Drug Des Devel Ther (2017)

“...Currently, a number of novel anticonvulsant drugs, the so-called third generation, are in various...”
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197

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Oxybutynin extended release for the management of overactive bladder: a clinical review

Por Arisco, AM, Brantly, EK, Kraus, SR
Publicado em 2009

“.... Nevertheless, bothersome side effects in addition to thrice daily dosing often led to treatment cessation which...”
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198

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Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections

Por Urbina, Olatz, Ferrández, Olivia, Espona, Mercè, Salas, Esther, Ferrández, Irene, Grau, Santiago
Publicado em 2013

“... with tedizolid when used at the therapeutic dose of 200 mg in Phase I, II, or III clinical trials of up to 3...”
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199

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Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition

Por Wagh, Dhananjay, Pothineni, Venkata Raveendra, Inayathullah, Mohammed, Liu, Song, Kim, Kwang-Min, Rajadas, Jayakumar
Publicado no Drug Des Devel Ther (2015)

“... binding to the in silico folded BmtA transporter. We, then, tested borreliacidal activity and dose...”
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200

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Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

Por Feng, Jiao, Chen, Kan, Xia, Yujing, Wu, Liwei, Li, Jingjing, Li, Sainan, Wang, Wenwen, Lu, Xiya, Liu, Tong, Guo, Chuanyong
Publicado no Drug Des Devel Ther (2018)

“... intraperitoneally at doses of 10 and 20 mg/kg once a day. Gene and protein expression levels were determined...”
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