Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

Bozepinib [(RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine] is a potent antitumor compound that is able to induce apoptosis in breast cancer cells. In the present study, we show that bozepinib also has antitumor activity in colon cancer cells, show...

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Библиографические подробности
Главные авторы: Marchal, Juan Antonio, Carrasco, Esther, Ramirez, Alberto, Jiménez, Gema, Olmedo, Carmen, Peran, Macarena, Agil, Ahmad, Conejo-García, Ana, Cruz-López, Olga, Campos, Joaquin María, García, María Ángel
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2013
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815003/
https://ncbi.nlm.nih.gov/pubmed/24194639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S51354
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