Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

Bozepinib [(RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine] is a potent antitumor compound that is able to induce apoptosis in breast cancer cells. In the present study, we show that bozepinib also has antitumor activity in colon cancer cells, show...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Marchal, Juan Antonio, Carrasco, Esther, Ramirez, Alberto, Jiménez, Gema, Olmedo, Carmen, Peran, Macarena, Agil, Ahmad, Conejo-García, Ana, Cruz-López, Olga, Campos, Joaquin María, García, María Ángel
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2013
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815003/
https://ncbi.nlm.nih.gov/pubmed/24194639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S51354
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares