Physiologically Based Pharmacokinetic Modeling Suggests Limited Drug–Drug Interaction Between Clopidogrel and Dasabuvir

Por Shebley, M, Fu, W, Badri, P, Bow, DAJ, Fischer, V
Publicado no Clin Pharmacol Ther (2017)

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

Por Puri, Anu, Loomis, Kristin, Smith, Brandon, Lee, Jae-Ho, Yavlovich, Amichai, Heldman, Eli, Blumenthal, Robert
Publicado em 2009

Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index

Por Bai, Jie, Wang, Rui-Hui, Qiao, Yan, Wang, Aidong, Fang, Chen-Jie
Publicado no Drug Des Devel Ther (2017)

Triazole derivatives with improved in vitro antifungal activity over azole drugs

Por Yu, Shichong, Chai, Xiaoyun, Wang, Yanwei, Cao, Yongbing, Zhang, Jun, Wu, Qiuye, Zhang, Dazhi, Jiang, Yuanying, Yan, Tianhua, Sun, Qingyan
Publicado em 2014

Physiologically based and population PK modeling in optimizing drug development: A predict–learn–confirm analysis

Por Suri, A, Chapel, S, Lu, C, Venkatakrishnan, K
Publicado no Clin Pharmacol Ther (2015)

Identification and Mechanistic Investigation of Drug–Drug Interactions Associated With Myopathy: A Translational Approach

Por Han, X, Quinney, SK, Wang, Z, Zhang, P, Duke, J, Desta, Z, Elmendorf, JS, Flockhart, DA, Li, L
Publicado no Clin Pharmacol Ther (2015)

Pediatric tuberculous meningitis: model-based approach to determining optimal doses of the anti-tuberculosis drugs rifampin and levofloxacin for children

Por Savic, Radojka M., Ruslami, Rovina, Hibma, Jennifer E., Hesseling, Anneke, Ramachandran, Geetha, Ganiem, A. Rizal, Swaminathan, Soumya, McIlleron, Helen, Gupta, Amita, Thakur, Kiran, van Crevel, Reinout, Aarnoutse, Rob, Dooley, Kelly E.
Publicado no Clin Pharmacol Ther (2015)

Discovery of Novel Second Mitochondria-Derived Activator of Caspase Mimetics as Selective Inhibitor of Apoptosis Protein Inhibitors

Por Wang, Jin, Li, Wei
Publicado em 2014

Synthetic biology for pharmaceutical drug discovery

Por Trosset, Jean-Yves, Carbonell, Pablo
Publicado no Drug Des Devel Ther (2015)

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

Por Tan, Cheau Yih, Lai, Ruenn Chai, Wong, Winnie, Dan, Yock Young, Lim, Sai-Kiang, Ho, Han Kiat
Publicado no Stem Cell Res Ther (2014)

Chitosan temperature-sensitive gel loaded with drug microspheres has excellent effectiveness, biocompatibility and safety as an ophthalmic drug delivery system

Por Kong, Xiaoying, Xu, Wenhua, Zhang, Cuiping, Kong, Wei
Publicado no Exp Ther Med (2018)

Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents

Por Revathi, Rajappan, Venkatesha Perumal, Ramachandran, Pai, Karkala Sreedhara Ranganath, Arunkumar, Govindakarnavar, Sriram, Dharmarajan, Kini, Suvarna Ganesh
Publicado no Drug Des Devel Ther (2015)

Genetics-Based Pediatric Warfarin Dosage Regimen Derived Using Pharmacometric Bridging

Por Lala, Mallika, Burckart, Gilbert J., Takao, Cheryl M., Pravica, Vera, Momper, Jeremiah D., Gobburu, Jogarao V.S.
Publicado em 2013

Phage therapy: An alternative to antibiotics in the age of multi-drug resistance

Por Lin, Derek M, Koskella, Britt, Lin, Henry C
Publicado no World J Gastrointest Pharmacol Ther (2017)

Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in-silico drug-repurposing analysis

Por Toro-Domínguez, Daniel, Carmona-Sáez, Pedro, Alarcón-Riquelme, Marta E.
Publicado no Arthritis Res Ther (2017)

Assessment of a Candidate Marker Constituent Predictive of a Dietary Substance–Drug Interaction: Case Study with Grapefruit Juice and CYP3A4 Drug Substrates

Por Ainslie, Garrett R., Wolf, Kristina K., Li, Yingxin, Connolly, Elizabeth A., Scarlett, Yolanda V., Hull, J. Heyward, Paine, Mary F.
Publicado no J Pharmacol Exp Ther (2014)

Digital technologies for cognitive assessment to accelerate drug development in Alzheimer's disease

Por Leurent, C, Ehlers, MD
Publicado no Clin Pharmacol Ther (2015)

Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery...

Por Chow, Maggie Zi, Boheler, Kenneth R, Li, Ronald A
Publicado em 2013

Milk derived colloid as a novel drug delivery carrier for breast cancer

Por Hayashi, Masamichi, Silanikove, Nissim, Chang, Xiaofei, Ravi, Rajani, Pham, Vui, Baia, Gilson, Paz, Keren, Brait, Mariana, Sidransky, David, Koch, Wayne M
Publicado no Cancer Biol Ther (2015)

Microdose-induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice

Por Zimmermann, Maike, Wang, Si-Si, Zhang, Hongyong, Lin, Tzu-yin, Malfatti, Michael, Haack, Kurt, Ognibene, Ted, Yang, Hongyuan, Airhart, Susan, Turteltaub, Kenneth W., Cimino, George D., Tepper, Clifford G., Drakaki, Alexandra, Chamie, Karim, de Vere White, Ralph, Pan, Chong-xian, Henderson, Paul T.
Publicado no Mol Cancer Ther (2016)