Pediatric tuberculous meningitis: model-based approach to determining optimal doses of the anti-tuberculosis drugs rifampin and levofloxacin for children

Pediatric TB meningitis (TBM) is a highly-morbid, oft-fatal disease. Standard treatment includes isoniazid, rifampin, pyrazinamide, and ethambutol. Current rifampin dosing achieves low cerebrospinal fluid (CSF) concentrations, and CSF penetration of ethambutol is poor. In adult trials, higher-dose r...

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Bibliographic Details
Published in:Clin Pharmacol Ther
Main Authors: Savic, Radojka M., Ruslami, Rovina, Hibma, Jennifer E., Hesseling, Anneke, Ramachandran, Geetha, Ganiem, A. Rizal, Swaminathan, Soumya, McIlleron, Helen, Gupta, Amita, Thakur, Kiran, van Crevel, Reinout, Aarnoutse, Rob, Dooley, Kelly E.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888594/
https://ncbi.nlm.nih.gov/pubmed/26260983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.202
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