Physiologically Based Pharmacokinetic Modeling Suggests Limited Drug–Drug Interaction Between Clopidogrel and Dasabuvir

Dasabuvir, a nonnucleoside NS5B polymerase inhibitor, is a sensitive substrate of cytochrome P450 (CYP) 2C8 with a potential for drug–drug interaction (DDI) with clopidogrel. A physiologically based pharmacokinetic (PBPK) model was developed for dasabuvir to evaluate the DDI potential with clopidogr...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Shebley, M, Fu, W, Badri, P, Bow, DAJ, Fischer, V
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599937/
https://ncbi.nlm.nih.gov/pubmed/28411400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.689
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