Quantitative Prediction of Drug–Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help?

This subteam under the Drug Metabolism Leadership Group (Innovation and Quality Consortium) investigated the quantitative role of circulating inhibitory metabolites in drug–drug interactions using physiologically based pharmacokinetic (PBPK) modeling. Three drugs with major circulating inhibitory me...

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Vydáno v:CPT Pharmacometrics Syst Pharmacol
Hlavní autoři: Templeton, IE, Chen, Y, Mao, J, Lin, J, Yu, H, Peters, S, Shebley, M, Varma, MV
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080647/
https://ncbi.nlm.nih.gov/pubmed/27642087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12110
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