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Genetics-Based Pediatric Warfarin Dosage Regimen Derived Using Pharmacometric Bridging

BACKGROUND: Warfarin dosage regimens using CYP2C9 and VKORC1 polymorphisms have been extensively studied in adults and is included in US Food and Drug Administration-approved warfarin labeling. However, no dosage algorithm is available for pediatric patients. OBJECTIVE: To derive a genetics-based pe...

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Detalhes bibliográficos
Main Authors: Lala, Mallika, Burckart, Gilbert J., Takao, Cheryl M., Pravica, Vera, Momper, Jeremiah D., Gobburu, Jogarao V.S.
Formato: Artigo
Idioma:Inglês
Publicado em: Pediatric Pharmacy Advocacy Group 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775555/
https://ncbi.nlm.nih.gov/pubmed/24052784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5863/1551-6776-18.3.209
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