Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide

Por Dong, Yuxiang, Lushnikova, Tamara, Golla, Radha M., Wang, Xiaofang, Wang, Guangshun
Publicado no Bioorg Med Chem (2016)

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity

Por Wagner, Jessica, Kline, Christina Leah, Pottorf, Richard S., Nallaganchu, Bhaskara Rao, Olson, Gary L., Dicker, David T., Allen, Joshua E., El-Deiry, Wafik S.
Publicado no Oncotarget (2015)

Pyrvinium attenuates Hedgehog signaling downstream of Smoothened

Por Li, Bin, Fei, Dennis Liang, Flaveny, Colin A., Dahmane, Nadia, Baubet, Valérie, Wang, Zhiqiang, Bai, Feng, Pei, Xin-Hai, Rodriguez-Blanco, Jezabel, Hang, Brian, Orton, Darren, Han, Lu, Wang, Baolin, Capobianco, Anthony J., Lee, Ethan, Robbins, David J.
Publicado no Cancer Res (2014)

Identification of a Small Molecule That Modulates Platelet Glycoprotein Ib-von Willebrand Factor Interaction

Por Broos, Katleen, Trekels, Mieke, Jose, Rani Alphonsa, Demeulemeester, Jonas, Vandenbulcke, Aline, Vandeputte, Nele, Venken, Tom, Egle, Brecht, De Borggraeve, Wim M., Deckmyn, Hans, De Maeyer, Marc
Publicado em 2012

Screening for Small Molecules' Bilayer-Modifying Potential Using a Gramicidin-Based Fluorescence Assay

Por Ingólfsson, Helgi I., Andersen, Olaf S.
Publicado em 2010

Bioactive Compounds from Marine Bacteria and Fungi

Por Debbab, Abdessamad, Aly, Amal H., Lin, Wen H., Proksch, Peter
Publicado em 2010

Antisecretory actions of a novel vasoactive intestinal polypeptide (VIP) antagonist in human and rat small intestine

Por Banks, Matthew R, Farthing, Michael J G, Robberecht, Patrick, Burleigh, David E
Publicado em 2005

Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia

Por Torres-Fuentes, Cristina, Pastor-Cavada, Elena, Cano, Rafael, Kandil, Dalia, Shanahan, Rachel, Juan, Rocio, Shaban, Hamdy, McGlacken, Gerard P., Schellekens, Harriët
Publicado no Int J Mol Sci (2018)

Identification of pyrazolopyridazinones as PDEδ inhibitors

Por Papke, Björn, Murarka, Sandip, Vogel, Holger A, Martín-Gago, Pablo, Kovacevic, Marija, Truxius, Dina C, Fansa, Eyad K, Ismail, Shehab, Zimmermann, Gunther, Heinelt, Kaatje, Schultz-Fademrecht, Carsten, Al Saabi, Alaa, Baumann, Matthias, Nussbaumer, Peter, Wittinghofer, Alfred, Waldmann, Herbert, Bastiaens, Philippe I.H.
Publicado no Nat Commun (2016)

Glyceraldehyde-3-phosphate dehydrogenase as a target for small-molecule disease-modifying therapies in human neurodegenerative disorders

Por Berry, Mark D.
Publicado em 2004

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

Por Ballatore, Carlo, Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B.
Publicado no ACS Chem Neurosci (2016)

Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis

Por Dai, Ping, Li, Jing, Ma, Xiao-Ping, Huang, Jian, Meng, Juan-Juan, Gong, Ping
Publicado no Onco Targets Ther (2018)

Antibiotic discovery throughout the Small World Initiative: A molecular strategy to identify biosynthetic gene clusters involved in antagonistic activity

Por Davis, Elizabeth, Sloan, Tyler, Aurelius, Krista, Barbour, Angela, Bodey, Elijah, Clark, Brigette, Dennis, Celeste, Drown, Rachel, Fleming, Megan, Humbert, Allison, Glasgo, Elizabeth, Kerns, Trent, Lingro, Kelly, McMillin, MacKenzie, Meyer, Aaron, Pope, Breanna, Stalevicz, April, Steffen, Brittney, Steindl, Austin, Williams, Carolyn, Wimberley, Carmen, Zenas, Robert, Butela, Kristen, Wildschutte, Hans
Publicado no Microbiologyopen (2017)

Are the physicochemical properties of antibacterial compounds really different from other drugs?

Por Ebejer, Jean-Paul, Charlton, Michael H., Finn, Paul W.
Publicado no J Cheminform (2016)

Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014–2015)

Por Ekins, Sean, Perryman, Alexander L., Clark, Alex M., Reynolds, Robert C., Freundlich, Joel S.
Publicado no J Chem Inf Model (2016)

Active machine learning-driven experimentation to determine compound effects on protein patterns

Por Naik, Armaghan W, Kangas, Joshua D, Sullivan, Devin P, Murphy, Robert F
Publicado no eLife (2016)

Small molecule inhibitors of IRES-mediated translation

Por Vaklavas, Christos, Meng, Zheng, Choi, Hyoungsoo, Grizzle, William E, Zinn, Kurt R, Blume, Scott W
Publicado no Cancer Biol Ther (2015)

Utilization of Flavonoid Compounds from Bark and Wood. III. Application in Health Foods

Por Ogawa, Sosuke, Matsuo, Yosuke, Tanaka, Takashi, Yazaki, Yoshikazu
Publicado no Molecules (2018)

Lipid droplet-associated proteins (LDAPs) are involved in the compartmentalization of lipophilic compounds in plant cells

Por Gidda, Satinder K, Watt, Samantha C, Collins-Silva, Jillian, Kilaru, Aruna, Arondel, Vincent, Yurchenko, Olga, Horn, Patrick J, James, Christopher N, Shintani, David, Ohlrogge, John B, Chapman, Kent D, Mullen, Robert T, Dyer, John M
Publicado em 2013

Maintenance therapy in non-small-cell lung cancer

Por Schmid-Bindert, Gerald
Publicado no Transl Lung Cancer Res (2012)