Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development

Por Vaklavas, Christos, Blume, Scott W., Grizzle, William E.
Publicado no Front Oncol (2017)

The human IGF1R IRES likely operates through a Shine-Dalgarno-like interaction with the G961 loop (E-site) of the 18S rRNA and is kinetically modulated by a naturally-polymorphic p...

Por Meng, Zheng, Jackson, Nateka L., Shcherbakov, Oleg D., Choi, Hyoungsoo, Blume, Scott W.
Publicado em 2010

Small molecule inhibitors of IRES-mediated translation

Por Vaklavas, Christos, Meng, Zheng, Choi, Hyoungsoo, Grizzle, William E, Zinn, Kurt R, Blume, Scott W
Publicado no Cancer Biol Ther (2015)

IRES inhibition induces terminal differentiation and synchronized death in triple-negative breast cancer and glioblastoma cells

Por Vaklavas, Christos, Grizzle, William E., Choi, Hyoungsoo, Meng, Zheng, Zinn, Kurt R., Shrestha, Kedar, Blume, Scott W.
Publicado no Tumour Biol (2016)

Translational control of the undifferentiated phenotype in ER-positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition

Por Vaklavas, Christos, Zinn, Kurt R., Samuel, Sharon L., Meng, Zheng, Grizzle, William E., Choi, Hyoungsoo, Blume, Scott W.
Publicado no Oncol Rep (2018)

Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R...

Por Blume, Scott W., Jackson, Nateka L., Frost, Andra R., Grizzle, William E., Shcherbakov, Oleg D., Choi, Hyoungsoo, Meng, Zheng
Publicado em 2010

The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

Por Meng, Zheng, King, Peter H., Nabors, L. Burt, Jackson, Nateka L., Chen, Ching-Yi, Emanuel, Peter D., Blume, Scott W.
Publicado em 2005

mrtl - a translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network

Por Choi, Hyoungsoo, Jackson, Nateka L., Shaw, Denise R., Emanuel, Peter D., Liu, Y. Lucy, Tousson, Albert, Meng, Zheng, Blume, Scott W.
Publicado em 2008