The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

The type I insulin-like growth factor receptor (IGF-IR) is an integral component in the control of cell proliferation, differentiation and apoptosis. The IGF-IR mRNA contains an extraordinarily long (1038 nt) 5′-untranslated region (5′-UTR), and we have characterized a diverse series of proteins int...

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Bibliographic Details
Main Authors: Meng, Zheng, King, Peter H., Nabors, L. Burt, Jackson, Nateka L., Chen, Ching-Yi, Emanuel, Peter D., Blume, Scott W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140080/
https://ncbi.nlm.nih.gov/pubmed/15914670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki603
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