Identification of a Small Molecule That Modulates Platelet Glycoprotein Ib-von Willebrand Factor Interaction

The von Willebrand factor (VWF) A1-glycoprotein (GP) Ibα interaction is of major importance during thrombosis mainly at sites of high shear stress. Inhibitors of this interaction prevent platelet-dependent thrombus formation in vivo, without major bleeding complications. However, the size and/or pro...

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Autors principals: Broos, Katleen, Trekels, Mieke, Jose, Rani Alphonsa, Demeulemeester, Jonas, Vandenbulcke, Aline, Vandeputte, Nele, Venken, Tom, Egle, Brecht, De Borggraeve, Wim M., Deckmyn, Hans, De Maeyer, Marc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308782/
https://ncbi.nlm.nih.gov/pubmed/22232560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311431
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