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Structural Basis of Regulation of von Willebrand Factor Binding to Glycoprotein Ib
Activation by elongational flow of von Willebrand factor (VWF) is critical for primary hemostasis. Mutations causing type 2B von Willebrand disease (VWD), platelet-type VWD (PT-VWD), and tensile force each increase affinity of the VWF A1 domain and platelet glycoprotein Ibα (GPIbα) for one another;...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937634/ https://ncbi.nlm.nih.gov/pubmed/24391089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.511220 |
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