Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα

Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynamic drag. The increased interaction requires shear-de...

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Detaylı Bibliyografya
Asıl Yazarlar: Gitz, Eelo, Koopman, Charlotte D., Giannas, Alèkos, Koekman, Cornelis A, van den Heuvel, Dave J., Deckmyn, Hans, Akkerman, Jan-Willem N., Gerritsen, Hans C., Urbanus, Rolf T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Ferrata Storti Foundation 2013
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815184/
https://ncbi.nlm.nih.gov/pubmed/23753027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.087221
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