Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα

Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynamic drag. The increased interaction requires shear-de...

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Auteurs principaux: Gitz, Eelo, Koopman, Charlotte D., Giannas, Alèkos, Koekman, Cornelis A, van den Heuvel, Dave J., Deckmyn, Hans, Akkerman, Jan-Willem N., Gerritsen, Hans C., Urbanus, Rolf T.
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815184/
https://ncbi.nlm.nih.gov/pubmed/23753027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.087221
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