Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα – 14-3-3ζ] association

BACKGROUND: Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, Bad activation and apoptosis. DESIGN AND METHODS: We i...

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Detalhes bibliográficos
Main Authors: van der Wal, Dianne E., Gitz, Eelo, Du, Vivian X., Lo, Kimberly S.L., Koekman, Cornelis A., Versteeg, Sabine, Akkerman, Jan Willem N.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487552/
https://ncbi.nlm.nih.gov/pubmed/22371179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.059956
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