Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes

BACKGROUND: In normal platelets, insulin inhibits agonist-induced Ca(2+) mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca(2+) mobilization, aggregation and procoagulant activity. We searched for the cause of this insulin r...

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Detalhes bibliográficos
Main Authors: Gerrits, Anja J., Gitz, Eelo, Koekman, Cornelis A., Visseren, Frank L., van Haeften, Timon W., Akkerman, Jan Willem N.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409811/
https://ncbi.nlm.nih.gov/pubmed/22491740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.054916
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