Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells

Tumor suppressor gene inactivation is a crucial event in oncogenesis. Gene inactivation mechanisms include events resulting in loss of heterozygosity (LOH), gene mutation, and transcriptional silencing. The contribution of each of these different pathways varies among tumor suppressor genes and by c...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Chan, Matilda F., van Amerongen, Renée, Nijjar, Tarlochan, Cuppen, Edwin, Jones, Peter A., Laird, Peter W.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2001
Fag:	DNA Dynamics and Chromosome Structure
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11604495/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.22.7587-7600.2001
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