Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells

Tumor suppressor gene inactivation is a crucial event in oncogenesis. Gene inactivation mechanisms include events resulting in loss of heterozygosity (LOH), gene mutation, and transcriptional silencing. The contribution of each of these different pathways varies among tumor suppressor genes and by c...

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Bibliographic Details
Main Authors: Chan, Matilda F., van Amerongen, Renée, Nijjar, Tarlochan, Cuppen, Edwin, Jones, Peter A., Laird, Peter W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC99930/
https://ncbi.nlm.nih.gov/pubmed/11604495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.22.7587-7600.2001
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