Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells

Tumor suppressor gene inactivation is a crucial event in oncogenesis. Gene inactivation mechanisms include events resulting in loss of heterozygosity (LOH), gene mutation, and transcriptional silencing. The contribution of each of these different pathways varies among tumor suppressor genes and by c...

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Detaylı Bibliyografya
Asıl Yazarlar: Chan, Matilda F., van Amerongen, Renée, Nijjar, Tarlochan, Cuppen, Edwin, Jones, Peter A., Laird, Peter W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2001
Konular:
DNA Dynamics and Chromosome Structure
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC99930/
https://ncbi.nlm.nih.gov/pubmed/11604495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.22.7587-7600.2001
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