Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells

Tumor suppressor gene inactivation is a crucial event in oncogenesis. Gene inactivation mechanisms include events resulting in loss of heterozygosity (LOH), gene mutation, and transcriptional silencing. The contribution of each of these different pathways varies among tumor suppressor genes and by c...

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Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главные авторы:	Chan, Matilda F., van Amerongen, Renée, Nijjar, Tarlochan, Cuppen, Edwin, Jones, Peter A., Laird, Peter W.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 2001
Предметы:	DNA Dynamics and Chromosome Structure
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11604495/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.22.7587-7600.2001
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