Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells

Tumor suppressor gene inactivation is a crucial event in oncogenesis. Gene inactivation mechanisms include events resulting in loss of heterozygosity (LOH), gene mutation, and transcriptional silencing. The contribution of each of these different pathways varies among tumor suppressor genes and by c...

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Bibliografski detalji
Izdano u:	Mol Cell Biol
Glavni autori:	Chan, Matilda F., van Amerongen, Renée, Nijjar, Tarlochan, Cuppen, Edwin, Jones, Peter A., Laird, Peter W.
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 2001
Teme:	DNA Dynamics and Chromosome Structure
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11604495/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.22.7587-7600.2001
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Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells

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