CpG Oligodeoxynucleotides and Interleukin-12 Improve the Efficacy of Mycobacterium bovis BCG Vaccination in Mice Challenged with M. tuberculosis

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine approved for prevention of tuberculosis. It has been postulated that serial passage of BCG over the years may have resulted in attenuation of its effectiveness. Because interleukin-12 (IL-12) and oligodeoxynucleotides (ODN) conta...

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Bibliographic Details

Published in:	Infect Immun
Main Authors:	Freidag, Brenda L., Melton, Genevieve B., Collins, Frank, Klinman, Dennis M., Cheever, Allen, Stobie, Laura, Suen, Winnie, Seder, Robert A.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2000
Subjects:	Microbial Immunity and Vaccines
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97508/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10768993/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.2948-2953.2000
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