CpG Oligodeoxynucleotides and Interleukin-12 Improve the Efficacy of Mycobacterium bovis BCG Vaccination in Mice Challenged with M. tuberculosis

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine approved for prevention of tuberculosis. It has been postulated that serial passage of BCG over the years may have resulted in attenuation of its effectiveness. Because interleukin-12 (IL-12) and oligodeoxynucleotides (ODN) conta...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Freidag, Brenda L., Melton, Genevieve B., Collins, Frank, Klinman, Dennis M., Cheever, Allen, Stobie, Laura, Suen, Winnie, Seder, Robert A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Microbial Immunity and Vaccines
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97508/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10768993/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.2948-2953.2000
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