Immunoglobulins in Nasal Secretions of Healthy Humans: Structural Integrity of Secretory Immunoglobulin A1 (IgA1) and Occurrence of Neutralizing Antibodies to IgA1 Proteases of Nasal Bacteria

Certain bacteria, including overt pathogens as well as commensals, produce immunoglobulin A1 (IgA1) proteases. By cleaving IgA1, including secretory IgA1, in the hinge region, these enzymes may interfere with the barrier functions of mucosal IgA antibodies, as indicated by experiments in vitro. Prev...

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Bibliographic Details
Main Authors: Kirkeby, Line, Rasmussen, Trine Tang, Reinholdt, Jesper, Kilian, Mogens
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Antibodies and Mediators of Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC95818/
https://ncbi.nlm.nih.gov/pubmed/10618273
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